CTNNB1(S45P)

26307

Size：100 μl Price：$ 495 Brand：NewEast Place of Origin：USA Immunogen：

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CTNNB1(S45P)

Cat. #: 26307

Gene Symbol: Beta-catenin, CTNNB, Catenin beta-1

Description: Anti-CTNNB1(S45P) Mouse Monoclonal Antibody

Background: CTNNB1 protein is a dual function protein. It is a subunit of a complex of proteins that from adherent junctions, which are important for the establishment and maintenance of epithelial cell layers by regulating cell growth and adhesion between adjacent cells. CTNNB1 protein also pulls double duty as an intracellular signal transducer in the Wnt signaling pathway. Mutations of CTNNB1 have been implicated in the pathogenesis of several cancers.

Immunogen: A synthetic peptide from the internal region of CTNNB1 which includes the mutation of S45P, human origin.

Applications: ELISA, IF, IHC

Recommended Dilutions:
ELISA: 1:1000-1:2000
IF: 1:50-1:100
IHC: 1:50-1:100

Concentration: 0.5 mg/ml

Host Species: Mouse

Format: Liquid

Clonality: Monoclonal

Isotype: IgG

Purity: Purified from ascites

Preservative: No

Constituents: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol

Species Reactivity: Recognizes S45P mutant, but not wild type CTNNB1 of vertebrates.

Storage Conditions: Store at -20°C. Avoid repeated freezing and thawing

Immunofluorescence::

Immunofluorescence of cells expressing CTNNB1 proteins with Anti-CTNNB1(S45P) antibody.

HEK293T cells were transfected with pCDNA3-GFP-CTNNB1 (S45P) plasmid, pCDNA3-GFP-CTNNB1 (WT) plasmid pCDNA3-GFP-CTNNB1 (S45F) plasmid or pCDNA3-GFP-CTNNB1 (S45Y) plasmid, then fixed and stained with Anti-CTNNB1(S45P) monoclonal antibody (Cat. #26307).

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CTNNB1(S45P)

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