CAPN6 Rabbit pAb

210181

Size：100 μl Price：$ 349 Brand：NewEast Place of Origin：USA Immunogen：

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Cat.#: S210181

Product Name: Anti-CAPN6 Rabbit Polyclonal Antibody

Synonyms: CANPX; CAPNX; CalpM; DJ914P14.1

UNIPROT ID: Q9Y6Q1 (Gene Accession - BC000730 )

Background: Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. The protein encoded by this gene is highly expressed in the placenta. Its C-terminal region lacks any homology to the calmodulin-like domain of other calpains. The protein lacks critical active site residues and thus is suggested to be proteolytically inactive. The protein may play a role in tumor formation by inhibiting apoptosis and promoting angiogenesis.

Immunogen: Fusion protein of human CAPN6

Applications: ELISA, WB, IHC

Recommended Dilutions: IHC: 50-100;WB: 500-2000;ELISA: 5000-10000

Host Species: Rabbit

Clonality: Rabbit Polyclonal

Isotype: Immunogen-specific rabbit IgG

Purification: Antigen affinity purification

Species Reactivity: Human, Mouse, Rat

Constituents: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol

Research Areas: Signal Transduction, Cell Biology

Storage & Shipping: Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human liver cancer tissue using 210181(CAPN6 Antibody) at a dilution of 1/70(Cytoplasm).	In comparision with the IHC on the left, the same paraffin-embedded Human liver cancer tissue is first treated with the fusion protein and then with 210181(Anti-CAPN6 Antibody) at dilution 1/70.
Gel: 8%SDS-PAGE, Lysate: 40 μg; Lane 1-2: TM4 and NIH/3T3 cell lysates; Primary antibody: 210181(CAPN6 Antibody) at dilution 1/500; Secondary antibody: HRP-conjugated Goat anti rabbit IgG at 1/5000 dilution; Exposure time: 15 seconds

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CAPN6 Rabbit pAb

TUBB3 Rabbit pAb

GAPDH Rabbit pAb

TUBA4A Rabbit pAb

ALB Rabbit pAb

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