PTPN6 Rabbit pAb

210583

Size：100 μl Price：$ 349 Brand：NewEast Place of Origin：USA Immunogen：

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Cat.#: S210583

Product Name: Anti-PTPN6 Rabbit Polyclonal Antibody

Synonyms: HCP; HCPH; SHP1; SHP-1; HPTP1C; PTP-1C; SHP-1L; SH-PTP1

UNIPROT ID: P29350 (Gene Accession - BC002523 )

Background: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported.

Immunogen: Fusion protein of human PTPN6

Applications: ELISA, WB, IHC

Recommended Dilutions: IHC: 50-200;WB: 200-1000;ELISA: 1000-2000

Host Species: Rabbit

Clonality: Rabbit Polyclonal

Isotype: Immunogen-specific rabbit IgG

Purification: Antigen affinity purification

Species Reactivity: Human, Mouse, Rat

Constituents: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol

Research Areas: Signal Transduction, Cancer, Developmental Biology

Storage & Shipping: Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human colon cancer tissue using 210583(PTPN6 Antibody) at a dilution of 1/35(Cytoplasm).	In comparision with the IHC on the left, the same paraffin-embedded Human colon cancer tissue is first treated with the fusion protein and then with 210583(Anti-PTPN6 Antibody) at dilution 1/35.
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using 210583(Anti-PTPN6 Antibody) at a dilution of 1/35.	In comparision with the IHC on the left, the same paraffin-embedded Human liver cancer tissue is first treated with fusion protein and then with D121215(Anti-PTPN6 Antibody) at dilution 1/35.
Gel: 10%SDS-PAGE, Lysate: 40 μg; Lane 1-2: A375 cells, A431 cells; Primary antibody: 210583(PTPN6 Antibody) at dilution 1/500; Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution; Exposure time: 90 seconds

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PTPN6 Rabbit pAb

TUBB3 Rabbit pAb

GAPDH Rabbit pAb

TUBA4A Rabbit pAb

ALB Rabbit pAb

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