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TIMP1 Rabbit pAb

210637

Size:100 μl Price:$ 349 Brand:NewEast Place of Origin:USA Immunogen:

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Cat.#:   S210637
Product Name:   Anti-TIMP1 Rabbit Polyclonal Antibody
Synonyms:   EPA; EPO; HCI; CLGI; TIMP
UNIPROT ID:   P01033 (Gene Accession - BC000866 )
Background:    This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction.
Immunogen:    Fusion protein of human TIMP1
Applications:    ELISA, IHC
Recommended Dilutions:    IHC: 15-50; ELISA: 1000-2000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Signal Transduction, Cardiovascular, Cell Biology
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human cervical cancer tissue using 210637(TIMP1 Antibody) at a dilution of 1/15(Cytoplasm ).

In comparision with the IHC on the left, the same paraffin-embedded Human cervical cancer tissue is first treated with the fusion protein and then with 210637(Anti-TIMP1 Antibody) at dilution 1/15.

The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using 210637(Anti-TIMP1 Antibody) at a dilution of 1/15.

In comparision with the IHC on the left, the same paraffin-embedded Human liver cancer tissue is first treated with fusion protein and then with D121341(Anti-TIMP1 Antibody) at dilution 1/15.
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