PRKAA2 Rabbit pAb

210778

Size：100 μl Price：$ 349 Brand：NewEast Place of Origin：USA Immunogen：

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Cat.#: S210778

Product Name: Anti-PRKAA2 Rabbit Polyclonal Antibody

Synonyms: AMPK; AMPK2; PRKAA; AMPKa2

UNIPROT ID: P54646 (Gene Accession - BC069680 )

Background: The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia.

Immunogen: Fusion protein of human PRKAA2

Applications: ELISA, IHC

Recommended Dilutions: IHC: 25-100; ELISA: 2000-5000

Host Species: Rabbit

Clonality: Rabbit Polyclonal

Isotype: Immunogen-specific rabbit IgG

Purification: Antigen affinity purification

Species Reactivity: Human, Mouse, Rat

Constituents: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol

Research Areas: Signal Transduction, Cancer, Metabolism, Cardiovascular

Storage & Shipping: Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human liver cancer tissue using 210778(PRKAA2 Antibody) at a dilution of 1/25(Cytoplasm).	In comparision with the IHC on the left, the same paraffin-embedded Human liver cancer tissue is first treated with the fusion protein and then with 210778(Anti-PRKAA2 Antibody) at dilution 1/25.
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using 210778(Anti-PRKAA2 Antibody) at a dilution of 1/25.	In comparision with the IHC on the left, the same paraffin-embedded Human thyroid cancer tissue is first treated with fusion protein and then with D121614(Anti-PRKAA2 Antibody) at dilution 1/25.

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