CPSF4 Rabbit pAb

211065

Size：100 μl Price：$ 349 Brand：NewEast Place of Origin：USA Immunogen：

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Cat.#: S211065

Product Name: Anti-CPSF4 Rabbit Polyclonal Antibody

Synonyms: NAR; NEB1; CPSF30

UNIPROT ID: O95639 (Gene Accession - BC003101 )

Background: Inhibition of the nuclear export of poly(A)-containing mRNAs caused by the influenza A virus NS1 protein requires its effector domain. The NS1 effector domain functionally interacts with the cellular 30 kDa subunit of cleavage and polyadenylation specific factor 4, an essential component of the 3' end processing machinery of cellular pre-mRNAs. In influenza virus-infected cells, the NS1 protein is physically associated with cleavage and polyadenylation specific factor 4, 30kD subunit. Binding of the NS1 protein to the 30 kDa protein in vitro prevents CPSF binding to the RNA substrate and inhibits 3' end cleavage and polyadenylation of host pre-mRNAs.

Immunogen: Fusion protein of human CPSF4

Applications: ELISA, IHC

Recommended Dilutions: IHC: 25-100; ELISA: 1000-2000

Host Species: Rabbit

Clonality: Rabbit Polyclonal

Isotype: Immunogen-specific rabbit IgG

Purification: Antigen affinity purification

Species Reactivity: Human, Mouse, Rat

Constituents: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol

Research Areas: Epigenetics and Nuclear Signaling

Storage & Shipping: Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human thyroid cancer tissue using 211065(CPSF4 Antibody) at a dilution of 1/30(Nucleus ).	In comparision with the IHC on the left, the same paraffin-embedded Human thyroid cancer tissue is first treated with the fusion protein and then with 211065(Anti-CPSF4 Antibody) at dilution 1/30.
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using 211065(Anti-CPSF4 Antibody) at a dilution of 1/30.	In comparision with the IHC on the left, the same paraffin-embedded Human brain tissue is first treated with fusion protein and then with D122145(Anti-CPSF4 Antibody) at dilution 1/30.

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CPSF4 Rabbit pAb

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