CYFIP2 Rabbit pAb

211080

Size：100 μl Price：$ 349 Brand：NewEast Place of Origin：USA Immunogen：

Add to cart

Download

Datasheet

MSDS

Product Description Reference citations(0) Related Products

Cat.#: S211080

Product Name: Anti-CYFIP2 Rabbit Polyclonal Antibody

Synonyms: PIR121

UNIPROT ID: Q96F07 (Gene Accession - BC011762 )

Background: CYFIP2 (Cytoplasmic FMR1-interacting protein 2, p53-inducible protein 121) is a 1,278 amino acid protein encoded by the human gene CYFIP2. CYFIP2 belongs to the CYFIP family and is involved in T-cell adhesion and p53-dependent induction of apoptosis. It interacts with FMR1, FXR1 and FXR2 and is a component of the WAVE1 complex composed of Abi-2, CYFIP2, C3orf10/HSPC300, NAP125 and WASF1/WAVE1. Upon binding to activated Rac 1, CYFIP2 causes the complex to dissociate, releasing activated WASF1. The CYFIP2 promoter contains a p53-responsive element that confers p53 binding as well as transcriptional activation of a heterologous reporter. Induced expression of CYFIP2 is sufficient for caspase activation and cellular apoptosis, reminiscent of p53 activation.

Immunogen: Fusion protein of human CYFIP2

Applications: ELISA, WB, IHC

Recommended Dilutions: IHC: 50-200;WB: 500-2000;ELISA: 2000-5000

Host Species: Rabbit

Clonality: Rabbit Polyclonal

Isotype: Immunogen-specific rabbit IgG

Purification: Antigen affinity purification

Species Reactivity: Human, Mouse

Constituents: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol

Research Areas: Cancer, Neuroscience, Immunology

Storage & Shipping: Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human liver cancer tissue using 211080(CYFIP2 Antibody) at a dilution of 1/25(Cytoplasm).	In comparision with the IHC on the left, the same paraffin-embedded Human liver cancer tissue is first treated with the fusion protein and then with 211080(Anti-CYFIP2 Antibody) at dilution 1/25.
The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using 211080(Anti-CYFIP2 Antibody) at a dilution of 1/25.	In comparision with the IHC on the left, the same paraffin-embedded Human gastric cancer tissue is first treated with fusion protein and then with D122175(Anti-CYFIP2 Antibody) at dilution 1/25.
Gel: 6%SDS-PAGE, Lysate: 40 μg; Lane 1-2: Mouse brain tissue, human fetal brain tissue; Primary antibody: 211080(CYFIP2 Antibody) at dilution 1/300; Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution; Exposure time: 2 minutes

Reference citations

No data available

Product Targets

Product Categories

CYFIP2 Rabbit pAb

TUBB3 Rabbit pAb

GAPDH Rabbit pAb

TUBA4A Rabbit pAb

ALB Rabbit pAb

Contant Us