LIMK1(Ab-508) Rabbit pAb

213300

Size：100 μl Price：$ 349 Brand：NewEast Place of Origin：USA Immunogen：

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Cat.#: S213300

Product Name: Anti-LIMK1(Ab-508) Rabbit Polyclonal Antibody

Synonyms: LIMK; LIMK-1

UNIPROT ID: P53667

Background: There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is a serine/threonine kinase that regulates actin polymerization via phosphorylation and inactivation of the actin binding factor cofilin. This protein is ubiquitously expressed during development and plays a role in many cellular processes associated with cytoskeletal structure. This protein also stimulates axon growth and may play a role in brain development. LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cognition of Williams syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Immunogen: Synthetic peptide of human LIMK1

Applications: WB, IHC

Recommended Dilutions: IHC: 30-150;WB: 500-2000;

Host Species: Rabbit

Clonality: Rabbit Polyclonal

Isotype: Immunogen-specific rabbit IgG

Purification: Antigen affinity purification

Species Reactivity: Human, Mouse, Rat

Constituents: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol

Research Areas: Signal Transduction, Neuroscience

Storage & Shipping: Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human liver cancer tissue using 213300(LIMK1(Ab-508) Antibody) at a dilution of 1/30(Cytoplasm).	In comparision with the IHC on the left, the same paraffin-embedded Human liver cancer tissue is first treated with the synthetic peptide and then with 213300(Anti-LIMK1(Anti-Ab-508) Antibody) at dilution 1/30.
Gel: 8%SDS-PAGE, Lysate: 40 μg; Lane: HUVEC cell lysate; Primary antibody: 213300(LIMK1(Ab-508) Antibody) at dilution 1/350; Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution; Exposure time: 30 seconds

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LIMK1(Ab-508) Rabbit pAb

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GAPDH Rabbit pAb

TUBA4A Rabbit pAb

ALB Rabbit pAb

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