ZAP70 ? Rabbit pAb

213311

Size：100 μl Price：$ 349 Brand：NewEast Place of Origin：USA Immunogen：

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Cat.#: S213311

Product Name: Anti-ZAP70 Rabbit Polyclonal Antibody

Synonyms: SRK; STD; TZK; STCD; ZAP-70

UNIPROT ID: P43403 (Gene Accession - NP_001070 )

Background: This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene.

Immunogen: Synthetic peptide of human ZAP70

Applications: ELISA, WB, IHC

Recommended Dilutions: IHC: 25-100;WB: 500-2000;ELISA: 2000-5000

Host Species: Rabbit

Clonality: Rabbit Polyclonal

Isotype: Immunogen-specific rabbit IgG

Purification: Antigen affinity purification

Species Reactivity: Human, Mouse

Constituents: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol

Research Areas: Signal Transduction, Immunology

Storage & Shipping: Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human thyroid cancer tissue using 213311(ZAP70 Antibody) at a dilution of 1/50(Cytoplasm ).	In comparision with the IHC on the left, the same paraffin-embedded Human thyroid cancer tissue is first treated with the synthetic peptide and then with 213311(Anti-ZAP70 Antibody) at dilution 1/50.
Gel: 10%SDS-PAGE, Lysate: 40 μg; Lane: Jurkat cells; Primary antibody: 213311(ZAP70 Antibody) at dilution 1/1000; Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution; Exposure time: 40 seconds

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ZAP70 ? Rabbit pAb

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