CCND1 Rabbit pAb

213467

Size：100 μl Price：$ 349 Brand：NewEast Place of Origin：USA Immunogen：

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Cat.#: S213467

Product Name: Anti-CCND1 Rabbit Polyclonal Antibody

Synonyms: BCL1, PRAD1, U21B31, D11S287E

UNIPROT ID: P24385 (Gene Accession - BC000076 )

Background: The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis.

Immunogen: Synthetic peptide of human CCND1

Applications: ELISA, IHC

Recommended Dilutions: IHC: Oct-50; ELISA: 500-5000

Host Species: Rabbit

Clonality: Rabbit Polyclonal

Isotype: Immunogen-specific rabbit IgG

Purification: Antigen affinity purification

Species Reactivity: Human, Mouse, Rat

Constituents: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol

Research Areas: Epigenetics and Nuclear Signaling, Cancer

Storage & Shipping: Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human breast cancer tissue using 213467(CCND1 Antibody) at a dilution of 1/25(Cytoplasm, Nucleus).	In comparision with the IHC on the left, the same paraffin-embedded Human breast cancer tissue is first treated with the synthetic peptide and then with 213467(Anti-CCND1 Antibody) at dilution 1/25.
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using 213467(Anti-CCND1 Antibody) at a dilution of 1/25.	In comparision with the IHC on the left, the same paraffin-embedded Human thyroid cancer tissue is first treated with synthetic peptide and then with D160236(Anti-CCND1 Antibody) at dilution 1/25.

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CCND1 Rabbit pAb

TUBB3 Rabbit pAb

GAPDH Rabbit pAb

TUBA4A Rabbit pAb

ALB Rabbit pAb

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