GRPR Rabbit pAb

213544

Size：100 μl Price：$ 349 Brand：NewEast Place of Origin：USA Immunogen：

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Cat.#: S213544

Product Name: Anti-GRPR Rabbit Polyclonal Antibody

Synonyms: BB2

UNIPROT ID: P30550 (Gene Accession - NP_005305 )

Background: Gastrin-releasing peptide (GRP) regulates numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation and is a potent mitogen for neoplastic tissues. The effects of GRP are mediated through the gastrin-releasing peptide receptor. This receptor is a glycosylated, 7-transmembrane G-protein coupled receptor that activates the phospholipase C signaling pathway. The receptor is aberrantly expressed in numerous cancers such as those of the lung, colon, and prostate. An individual with autism and multiple exostoses was found to have a balanced translocation between chromosome 8 and a chromosome X breakpoint located within the gastrin-releasing peptide receptor gene.

Immunogen: Synthetic peptide of human GRPR

Applications: ELISA, WB, IHC

Recommended Dilutions: IHC: 50-200;WB: 200-1000;ELISA: 2000-5000

Host Species: Rabbit

Clonality: Rabbit Polyclonal

Isotype: Immunogen-specific rabbit IgG

Purification: Antigen affinity purification

Species Reactivity: Human, Mouse, Rat

Constituents: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol

Research Areas: Signal Transduction, Neuroscience

Storage & Shipping: Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human cervical cancer tissue using 213544(GRPR Antibody) at a dilution of 1/40(Cytoplasm).	In comparision with the IHC on the left, the same paraffin-embedded Human cervical cancer tissue is first treated with the synthetic peptide and then with 213544(Anti-GRPR Antibody) at dilution 1/40.
The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using 213544(Anti-GRPR Antibody) at a dilution of 1/40.	In comparision with the IHC on the left, the same paraffin-embedded Human esophagus cancer tissue is first treated with synthetic peptide and then with D160388(Anti-GRPR Antibody) at dilution 1/40.
Gel: 8%SDS-PAGE, Lysate: 40 μg; Lane 1-2: Human hepatocellular carcinoma tissue, A549 cells; Primary antibody: 213544(GRPR Antibody) at dilution 1/300; Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution; Exposure time: 5 minutes

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GRPR Rabbit pAb

TUBB3 Rabbit pAb

GAPDH Rabbit pAb

TUBA4A Rabbit pAb

ALB Rabbit pAb

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