PFN2 Rabbit pAb

213717

Size：100 μl Price：$ 349 Brand：NewEast Place of Origin：USA Immunogen：

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Cat.#: S213717

Product Name: Anti-PFN2 Rabbit Polyclonal Antibody

Synonyms: PFL, D3S1319E

UNIPROT ID: P35080 (Gene Accession - NP_444252 )

Background: The protein encoded by this gene is a ubiquitous actin monomer-binding protein belonging to the profilin family. It is thought to regulate actin polymerization in response to extracellular signals. There are two alternatively spliced transcript variants encoding different isoforms described for this gene. Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG.

Immunogen: Synthetic peptide of human PFN2

Applications: ELISA, WB, IHC

Recommended Dilutions: IHC: 25-100;WB: 500-2000;ELISA: 1000-5000

Host Species: Rabbit

Clonality: Rabbit Polyclonal

Isotype: Immunogen-specific rabbit IgG

Purification: Antigen affinity purification

Species Reactivity: Human, Mouse, Rat

Constituents: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol

Research Areas: Signal Transduction

Storage & Shipping: Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human brain tissue using 213717(PFN2 Antibody) at a dilution of 1/30(Cytoplasm).	In comparision with the IHC on the left, the same paraffin-embedded Human brain tissue is first treated with the synthetic peptide and then with 213717(Anti-PFN2 Antibody) at dilution 1/30.
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using 213717(Anti-PFN2 Antibody) at a dilution of 1/30.	In comparision with the IHC on the left, the same paraffin-embedded Human liver cancer tissue is first treated with synthetic peptide and then with D160712(Anti-PFN2 Antibody) at dilution 1/30.
Gel: 10%SDS-PAGE, Lysate: 40 μg; Lane: Human fetal brain tissue; Primary antibody: 213717(PFN2 Antibody) at dilution 1/450; Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution; Exposure time: 3 minutes

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PFN2 Rabbit pAb

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