TCF7 Rabbit pAb

213753

Size：100 μl Price：$ 349 Brand：NewEast Place of Origin：USA Immunogen：

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Cat.#: S213753

Product Name: Anti-TCF7 Rabbit Polyclonal Antibody

Synonyms: TCF-1

UNIPROT ID: P36402 (Gene Accession - NP_001128323 )

Background: This gene encodes a member of the T-cell factor/lymphoid enhancer-binding factor family of high mobility group (HMG) box transcriptional activators. This gene is expressed predominantly in T-cells and plays a critical role in natural killer cell and innate lymphoid cell development. The encoded protein forms a complex with beta-catenin and activates transcription through a Wnt/beta-catenin signaling pathway. Mice with a knockout of this gene are viable and fertile, but display a block in T-lymphocyte differentiation. Alternative splicing results in multiple transcript variants. Naturally-occurring isoforms lacking the N-terminal beta-catenin interaction domain may act as dominant negative regulators of Wnt signaling.

Immunogen: Synthetic peptide of human TCF7

Applications: ELISA, IHC

Recommended Dilutions: IHC: 40-200; ELISA: 5000-10000

Host Species: Rabbit

Clonality: Rabbit Polyclonal

Isotype: Immunogen-specific rabbit IgG

Purification: Antigen affinity purification

Species Reactivity: Human, Mouse

Constituents: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol

Research Areas: Epigenetics and Nuclear Signaling, Immunology, Signal Transduction

Storage & Shipping: Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human lung cancer tissue using 213753(TCF7 Antibody) at a dilution of 1/30(Nucleus).	In comparision with the IHC on the left, the same paraffin-embedded Human lung cancer tissue is first treated with the synthetic peptide and then with 213753(Anti-TCF7 Antibody) at dilution 1/30.
The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using 213753(Anti-TCF7 Antibody) at a dilution of 1/30.	In comparision with the IHC on the left, the same paraffin-embedded Human prostate cancer tissue is first treated with synthetic peptide and then with D160768(Anti-TCF7 Antibody) at dilution 1/30.

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TCF7 Rabbit pAb

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