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Call Us：(+1) 610-945-2007
Size：100 μl
Price：$ 349
Brand：NewEast 
Place of Origin：USA
Immunogen：
| Cat.#: S213779 | ||||
| Product Name: Anti-ABCD2 Rabbit Polyclonal Antibody | ||||
| Synonyms: ALDR; ABC39; ALDL1; ALDRP; hALDR | ||||
| UNIPROT ID: Q9UBJ2 (Gene Accession - NP_005155 ) | ||||
| Background: The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. The function of this peroxisomal membrane protein is unknown; however this protein is speculated to function as a dimerization partner of ABCD1 and/or other peroxisomal ABC transporters. Mutations in this gene have been observed in patients with adrenoleukodystrophy, a severe demyelinating disease. This gene has been identified as a candidate for a modifier gene, accounting for the extreme variation among adrenoleukodystrophy phenotypes. This gene is also a candidate for a complement group of Zellweger syndrome, a genetically heterogeneous disorder of peroxisomal biogenesis. | ||||
| Immunogen: Synthetic peptide of human ABCD2 | ||||
| Applications: ELISA, IHC | ||||
| Recommended Dilutions: IHC: 25-100; ELISA: 2000-5000 | ||||
| Host Species: Rabbit | ||||
| Clonality: Rabbit Polyclonal | ||||
| Isotype: Immunogen-specific rabbit IgG | ||||
| Purification: Antigen affinity purification | ||||
| Species Reactivity: Human, Mouse, Rat | ||||
| Constituents: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol | ||||
| Research Areas: Metabolism, Cancer, Cardiovascular | ||||
| Storage & Shipping: Store at -20°C. Avoid repeated freezing and thawing | ||||
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