SMG8 Rabbit pAb

213845

Size：100 μl Price：$ 349 Brand：NewEast Place of Origin：USA Immunogen：

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Cat.#: S213845

Product Name: Anti-SMG8 Rabbit Polyclonal Antibody

Synonyms: C17orf71

UNIPROT ID: Q8ND04 (Gene Accession - NP_060619 )

Background: Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited by release factors to stalled ribosomes together with SMG1 and SMG9 (forming the SMG1C protein kinase complex) and, in the SMG1C comple,x is required to mediate the recruitment of SMG1 to the ribosome:SURF complex and to suppress SMG1 kinase activity until the ribosome:SURF complex locates the exon junction complex (EJC). Acts as a regulator of kinase activity.

Immunogen: Synthetic peptide of human SMG8

Applications: ELISA, IHC

Recommended Dilutions: IHC: 25-100; ELISA: 2000-5000

Host Species: Rabbit

Clonality: Rabbit Polyclonal

Isotype: Immunogen-specific rabbit IgG

Purification: Antigen affinity purification

Species Reactivity: Human, Mouse

Constituents: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol

Research Areas: Cancer

Storage & Shipping: Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human colon cancer tissue using 213845(SMG8 Antibody) at a dilution of 1/50(Cytoplasm).	In comparision with the IHC on the left, the same paraffin-embedded Human colon cancer tissue is first treated with the synthetic peptide and then with 213845(Anti-SMG8 Antibody) at dilution 1/50.
The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using 213845(Anti-SMG8 Antibody) at a dilution of 1/50.	In comparision with the IHC on the left, the same paraffin-embedded Human lung cancer tissue is first treated with synthetic peptide and then with D160943(Anti-SMG8 Antibody) at dilution 1/50.

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