MCAM Rabbit pAb

213885

Size：100 μl Price：$ 349 Brand：NewEast Place of Origin：USA Immunogen：

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Cat.#: S213885

Product Name: Anti-MCAM Rabbit Polyclonal Antibody

Synonyms: CD146; MUC18; HEMCAM; METCAM; MelCAM

UNIPROT ID: P43121 (Gene Accession - NP_006491 )

Background: Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration.

Immunogen: Synthetic peptide of human MCAM

Applications: ELISA, WB, IHC

Recommended Dilutions: IHC: 40-200;WB: 500-2000;ELISA: 5000-10000

Host Species: Rabbit

Clonality: Rabbit Polyclonal

Isotype: Immunogen-specific rabbit IgG

Purification: Antigen affinity purification

Species Reactivity: Human

Constituents: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol

Research Areas: Signal Transduction, Cardiovascular, Immunology, Stem Cells

Storage & Shipping: Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human thyroid cancer tissue using 213885(MCAM Antibody) at a dilution of 1/40(Cell membrane).	In comparision with the IHC on the left, the same paraffin-embedded Human thyroid cancer tissue is first treated with the synthetic peptide and then with 213885(Anti-MCAM Antibody) at dilution 1/40.
The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using 213885(Anti-MCAM Antibody) at a dilution of 1/40.	In comparision with the IHC on the left, the same paraffin-embedded Human ovarian cancer tissue is first treated with synthetic peptide and then with D161008(Anti-MCAM Antibody) at dilution 1/40.
Gel: 6%SDS-PAGE, Lysate: 40 μg; Lane: Human leiomyosarcoma tissue lysate; Primary antibody: 213885(MCAM Antibody) at dilution 1/400; Secondary antibody: HRP-conjugated Goat anti rabbit IgG at 1/5000 dilution; Exposure time: 5 seconds

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MCAM Rabbit pAb

TUBB3 Rabbit pAb

GAPDH Rabbit pAb

TUBA4A Rabbit pAb

ALB Rabbit pAb

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