PARP1 (cleaved) Rabbit pAb

213928

Size：100 μl Price：$ 349 Brand：NewEast Place of Origin：USA Immunogen：

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Cat.#: S213928

Product Name: Anti-PARP1 (cleaved) Rabbit Polyclonal Antibody

Synonyms: PARP; PARS; PPOL; ADPRT; ARTD1; ADPRT1; PARP-1; ADPRT 1; pADPRT-1; Poly-PARP

UNIPROT ID: P09874 (Gene Accession - NP_001609 )

Background: This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes.

Immunogen: Synthetic peptide of human PARP1

Applications: ELISA, WB, IHC

Recommended Dilutions: IHC: 25-100;WB: 500-2000;ELISA: 1000-5000

Host Species: Rabbit

Clonality: Rabbit Polyclonal

Isotype: Immunogen-specific rabbit IgG

Purification: Antigen affinity purification

Species Reactivity: Human, Mouse, Rat

Constituents: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol

Research Areas: Epigenetics and Nuclear Signaling, Cancer

Storage & Shipping: Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human cervical cancer tissue using 213928(PARP1(cleaved) Antibody) at a dilution of 1/25(Cytoplasm, Nucleus).	In comparision with the IHC on the left, the same paraffin-embedded Human cervical cancer tissue is first treated with the synthetic peptide and then with 213928(Anti-PARP1(Anti-cleaved) Antibody) at dilution 1/25.
The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using 213928(Anti-PARP1(Anti-cleaved) Antibody) at a dilution of 1/25.	In comparision with the IHC on the left, the same paraffin-embedded Human breast cancer tissue is first treated with synthetic peptide and then with D161072(Anti-PARP1(Anti-cleaved) Antibody) at dilution 1/25.
Gel: 6%SDS-PAGE, Lysate: 40 μg; Lane: Hela cell lysate; Primary antibody: 213928(PARP1 (cleaved) Antibody) at dilution 1/500; Secondary antibody: HRP-conjugated Goat anti rabbit IgG at 1/5000 dilution; Exposure time: 3 minutes

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PARP1 (cleaved) Rabbit pAb

TUBB3 Rabbit pAb

GAPDH Rabbit pAb

TUBA4A Rabbit pAb

ALB Rabbit pAb

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