AKAP12 Rabbit pAb

213978

Size：100 μl Price：$ 349 Brand：NewEast Place of Origin：USA Immunogen：

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Cat.#: S213978

Product Name: Anti-AKAP12 Rabbit Polyclonal Antibody

Synonyms: SSeCKS; AKAP250

UNIPROT ID: Q02952 (Gene Accession - NP_005091 )

Background: The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is expressed in endothelial cells, cultured fibroblasts, and osteosarcoma cells. It associates with protein kinases A and C and phosphatase, and serves as a scaffold protein in signal transduction. This protein and RII PKA colocalize at the cell periphery. This protein is a cell growth-related protein. Antibodies to this protein can be produced by patients with myasthenia gravis. Alternative splicing of this gene results in two transcript variants encoding different isoforms.

Immunogen: Synthetic peptide of human AKAP12

Applications: ELISA, IHC

Recommended Dilutions: IHC: 50-200; ELISA: 3000-10000

Host Species: Rabbit

Clonality: Rabbit Polyclonal

Isotype: Immunogen-specific rabbit IgG

Purification: Antigen affinity purification

Species Reactivity: Human

Constituents: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol

Research Areas: Signal Transduction, Neuroscience

Storage & Shipping: Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human brain tissue using 213978(AKAP12 Antibody) at a dilution of 1/40(Cytoplasm ).	In comparision with the IHC on the left, the same paraffin-embedded Human brain tissue is first treated with the synthetic peptide and then with 213978(Anti-AKAP12 Antibody) at dilution 1/40.
The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using 213978(Anti-AKAP12 Antibody) at a dilution of 1/40.	In comparision with the IHC on the left, the same paraffin-embedded Human lung cancer tissue is first treated with synthetic peptide and then with D161143(Anti-AKAP12 Antibody) at dilution 1/40.

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