FZD6 Rabbit pAb

214022

Size：100 μl Price：$ 349 Brand：NewEast Place of Origin：USA Immunogen：

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Cat.#: S214022

Product Name: Anti-FZD6 Rabbit Polyclonal Antibody

Synonyms: FZ6; FZ-6; HFZ6; NDNC10

UNIPROT ID: O60353 (Gene Accession - NP_001158087 )

Background: This gene represents a member of the 'frizzled' gene family, which encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The protein encoded by this family member contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains, but unlike other family members, this protein does not contain a C-terminal PDZ domain-binding motif. This protein functions as a negative regulator of the canonical Wnt/beta-catenin signaling cascade, thereby inhibiting the processes that trigger oncogenic transformation, cell proliferation, and inhibition of apoptosis. Alternative splicing results in multiple transcript variants, some of which do not encode a protein with a predicted signal peptide.

Immunogen: Synthetic peptide of human FZD6

Applications: ELISA, IHC

Recommended Dilutions: IHC: 100-300; ELISA: 2000-10000

Host Species: Rabbit

Clonality: Rabbit Polyclonal

Isotype: Immunogen-specific rabbit IgG

Purification: Antigen affinity purification

Species Reactivity: Human, Mouse

Constituents: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol

Research Areas: Signal Transduction

Storage & Shipping: Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human thyroid cancer tissue using 214022(FZD6 Antibody) at a dilution of 1/60(Cytoplasm).	In comparision with the IHC on the left, the same paraffin-embedded Human thyroid cancer tissue is first treated with the synthetic peptide and then with 214022(Anti-FZD6 Antibody) at dilution 1/60.
The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using 214022(Anti-FZD6 Antibody) at a dilution of 1/60.	In comparision with the IHC on the left, the same paraffin-embedded Human gastric cancer tissue is first treated with synthetic peptide and then with D161205(Anti-FZD6 Antibody) at dilution 1/60.

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FZD6 Rabbit pAb

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