ACO1 Rabbit pAb

214031

Size：100 μl Price：$ 349 Brand：NewEast Place of Origin：USA Immunogen：

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Cat.#: S214031

Product Name: Anti-ACO1 Rabbit Polyclonal Antibody

Synonyms: IRP1; ACONS; IREB1; IREBP; IREBP1

UNIPROT ID: P21399 (Gene Accession - NP_002188 )

Background: Aconitase 1, also known as iron regulatory element binding protein 1 (IREB1), is a cytosolic protein which binds to iron-responsive elements (IREs). IREs are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. The iron-induced binding to the IRE results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degrading transferrin receptor mRNA. Thus, IREB1 plays a central role in cellular iron homeostasis. It was also shown to have aconitase activity, and hence grouped with the aconitase family of enzymes.

Immunogen: Synthetic peptide of human ACO1

Applications: ELISA, IHC

Recommended Dilutions: IHC: 50-200; ELISA: 2000-10000

Host Species: Rabbit

Clonality: Rabbit Polyclonal

Isotype: Immunogen-specific rabbit IgG

Purification: Antigen affinity purification

Species Reactivity: Human, Mouse, Rat

Constituents: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol

Research Areas: Metabolism, Epigenetics and Nuclear Signaling, Cardiovascular

Storage & Shipping: Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human liver cancer tissue using 214031(ACO1 Antibody) at a dilution of 1/50(Cytoplasm).	In comparision with the IHC on the left, the same paraffin-embedded Human liver cancer tissue is first treated with the synthetic peptide and then with 214031(Anti-ACO1 Antibody) at dilution 1/50.
The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using 214031(Anti-ACO1 Antibody) at a dilution of 1/50.	In comparision with the IHC on the left, the same paraffin-embedded Human lung cancer tissue is first treated with synthetic peptide and then with D161223(Anti-ACO1 Antibody) at dilution 1/50.

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