PFKFB1 Rabbit pAb

214125

Size：100 μl Price：$ 349 Brand：NewEast Place of Origin：USA Immunogen：

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Cat.#: S214125

Product Name: Anti-PFKFB1 Rabbit Polyclonal Antibody

Synonyms: F6PK; HL2K; PFRX

UNIPROT ID: P16118 (Gene Accession - NP_002616 )

Background: This gene encodes a member of the family of bifunctional 6-phosphofructo-2-kinase:fructose-2,6-biphosphatase enzymes. The enzyme forms a homodimer that catalyzes both the synthesis and degradation of fructose-2,6-biphosphate using independent catalytic domains. Fructose-2,6-biphosphate is an activator of the glycolysis pathway and an inhibitor of the gluconeogenesis pathway. Consequently, regulating fructose-2,6-biphosphate levels through the activity of this enzyme is thought to regulate glucose homeostasis. Multiple alternatively spliced transcript variants have been found for this gene.

Immunogen: Synthetic peptide of human PFKFB1

Applications: ELISA, IHC

Recommended Dilutions: IHC: 50-200; ELISA: 1000-5000

Host Species: Rabbit

Clonality: Rabbit Polyclonal

Isotype: Immunogen-specific rabbit IgG

Purification: Antigen affinity purification

Species Reactivity: Human, Mouse, Rat

Constituents: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol

Research Areas: Metabolism, Cancer

Storage & Shipping: Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human liver cancer tissue using 214125(PFKFB1 Antibody) at a dilution of 1/60(Cytoplasm).	In comparision with the IHC on the left, the same paraffin-embedded Human liver cancer tissue is first treated with the synthetic peptide and then with 214125(Anti-PFKFB1 Antibody) at dilution 1/60.
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using 214125(Anti-PFKFB1 Antibody) at a dilution of 1/60.	In comparision with the IHC on the left, the same paraffin-embedded Human brain tissue is first treated with synthetic peptide and then with D161388(Anti-PFKFB1 Antibody) at dilution 1/60.

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