CAV1 Rabbit pAb

214147

Size：100 μl Price：$ 349 Brand：NewEast Place of Origin：USA Immunogen：

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Cat.#: S214147

Product Name: Anti-CAV1 Rabbit Polyclonal Antibody

Synonyms: CGL3; PPH3; BSCL3; VIP21; MSTP085

UNIPROT ID: Q03135 (Gene Accession - NP_001744 )

Background: The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 mitogen-activated kinase cascade. Caveolin 1 and caveolin 2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. Mutations in this gene have been associated with Berardinelli-Seip congenital lipodystrophy. Alternatively spliced transcripts encode alpha and beta isoforms of caveolin 1.

Immunogen: Synthetic peptide of human CAV1

Applications: ELISA, WB, IHC

Recommended Dilutions: IHC: 50-200;WB: 1000-5000;ELISA: 2000-10000

Host Species: Rabbit

Clonality: Rabbit Polyclonal

Isotype: Immunogen-specific rabbit IgG

Purification: Antigen affinity purification

Species Reactivity: Human, Mouse, Rat

Constituents: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol

Research Areas: Signal Transduction, Cancer

Storage & Shipping: Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human esophagus cancer tissue using 214147(CAV1 Antibody) at a dilution of 1/40(Cytoplasm).	In comparision with the IHC on the left, the same paraffin-embedded Human esophagus cancer tissue is first treated with the synthetic peptide and then with 214147(Anti-CAV1 Antibody) at dilution 1/40.
The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using 214147(Anti-CAV1 Antibody) at a dilution of 1/40.	In comparision with the IHC on the left, the same paraffin-embedded Human cervical cancer tissue is first treated with synthetic peptide and then with D161423(Anti-CAV1 Antibody) at dilution 1/40.
Gel: 10%SDS-PAGE, Lysate: 40 μg; Lane 1-6: Human fetal muscle tissue, Human fetal lung tissue, Human leiomyosarcoma tissue, mouse lung, Mouse heart tissue, NIH/3T3 cells; Primary antibody: 214147(CAV1 Antibody) at dilution 1/550; Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution; Exposure time: 10 seconds

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Product Categories

CAV1 Rabbit pAb

TUBB3 Rabbit pAb

GAPDH Rabbit pAb

TUBA4A Rabbit pAb

ALB Rabbit pAb

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