CCDC88A Rabbit pAb

214158

Size：100 μl Price：$ 349 Brand：NewEast Place of Origin：USA Immunogen：

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Cat.#: S214158

Product Name: Anti-CCDC88A Rabbit Polyclonal Antibody

Synonyms: APE; GIV; GRDN; HkRP1; GIRDIN; KIAA1212

UNIPROT ID: Q3V6T2 (Gene Accession - NP_001129069 )

Background: This gene encodes a member of the Girdin family of coiled-coil domain containing proteins. The encoded protein is an actin-binding protein that is activated by the serine/threonine kinase Akt and plays a role in cytoskeleton remodeling and cell migration. The encoded protein also enhances Akt signaling by mediating phosphoinositide 3-kinase (PI3K)-dependent activation of Akt by growth factor receptor tyrosine kinases and G protein-coupled receptors. Increased expression of this gene and phosphorylation of the encoded protein may play a role in cancer metastasis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Immunogen: Synthetic peptide of human CCDC88A

Applications: ELISA, IHC

Recommended Dilutions: IHC: 50-200; ELISA: 1000-5000

Host Species: Rabbit

Clonality: Rabbit Polyclonal

Isotype: Immunogen-specific rabbit IgG

Purification: Antigen affinity purification

Species Reactivity: Human, Mouse

Constituents: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol

Research Areas: Signal Transduction, Neuroscience

Storage & Shipping: Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human cervical cancer tissue using 214158(CCDC88A Antibody) at a dilution of 1/50(Cytoplasm).	In comparision with the IHC on the left, the same paraffin-embedded Human cervical cancer tissue is first treated with the synthetic peptide and then with 214158(Anti-CCDC88A Antibody) at dilution 1/50.
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using 214158(Anti-CCDC88A Antibody) at a dilution of 1/50.	In comparision with the IHC on the left, the same paraffin-embedded Human colon cancer tissue is first treated with synthetic peptide and then with D161438(Anti-CCDC88A Antibody) at dilution 1/50.

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