TP53INP1 Rabbit pAb

214555

Size：100 μl Price：$ 349 Brand：NewEast Place of Origin：USA Immunogen：

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Cat.#: S214555

Product Name: Anti-TP53INP1 Rabbit Polyclonal Antibody

Synonyms: SIP; Teap; p53DINP1; TP53DINP1; TP53INP1A; TP53INP1B

UNIPROT ID: Q96A56 (Gene Accession - NP_150601 )

Background: TP53INP1 (tumor protein p53-inducible nuclear protein 1), also known as p53DINP1, SIP or Teap, is a 240 amino acid protein that localizes to nuclear bodies and exists as two alternatively spliced isoforms, designated p53DINP1a and p53DINP1b. Expressed ubiquitously with higher expression in testis, pancreas and spleen tissue, TP53INP1 functions in response to double-stranded DNA breaks and regulates p53-mediated apoptosis, specifically by phosphorylating human p53 at Ser 46, an event that leads to cell death. Additionally, TP53INP1 is thought to interact with p73 and may be involved in the regulation of p73-controlled cell cycle progression. TP53INP1 expression is downregulated in pancreatic ductal adenocarcinomas, suggesting that, via its ability to induce cell death, TP53INP1 plays a role in tumor suppression.

Immunogen: Synthetic peptide of human TP53INP1

Applications: ELISA, WB, IHC

Recommended Dilutions: IHC: 50-200;WB: 200-1000;ELISA: 1000-2000

Host Species: Rabbit

Clonality: Rabbit Polyclonal

Isotype: Immunogen-specific rabbit IgG

Purification: Antigen affinity purification

Species Reactivity: Human

Constituents: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol

Research Areas: Cancer

Storage & Shipping: Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human brain tissue using 214555(TP53INP1 Antibody) at a dilution of 1/50(Cytoplasm).	In comparision with the IHC on the left, the same paraffin-embedded Human brain tissue is first treated with the synthetic peptide and then with 214555(Anti-TP53INP1 Antibody) at dilution 1/50.
The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using 214555(Anti-TP53INP1 Antibody) at a dilution of 1/50.	In comparision with the IHC on the left, the same paraffin-embedded Human prostate cancer tissue is first treated with synthetic peptide and then with D162004(Anti-TP53INP1 Antibody) at dilution 1/50.
Gel: 10%SDS-PAGE, Lysate: 40 μg; Lane 1-3: Human fetal liver tissue, 293T cells, 231 cells; Primary antibody: 214555(TP53INP1 Antibody) at dilution 1/200; Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution; Exposure time: 1 minute

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TP53INP1 Rabbit pAb

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