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SYCP1 Rabbit pAb

214654

Size:100 μl Price:$ 349 Brand:NewEast Place of Origin:USA Immunogen:

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Cat.#:   S214654
Product Name:   Anti-SYCP1 Rabbit Polyclonal Antibody
Synonyms:   CT8; SCP1; SCP-1; HOM-TES-14
UNIPROT ID:   Q15431 (Gene Accession - NP_003167 )
Background:    The synaptonemal complex protein 1 (SCP-1), also known as SYCP1(A), SYN1(I) and HOM-TES-14, is a protein product of human chromosome 1p13-p12. SCP-1 is a major component of the transverse filaments of synaptonemal complexes and functions by pairing homologous chromosomes during meiotic prophase in spermatocytes, which is an essential step for the generation of haploid cells in meiosis I. SCP-1 is expressed in the testis, adult brain, some malignant gliomas, breast, renal cell and ovarian cancer. SCP-1 is known to be selectively expressed during the meiotic prophase of spermatocytes and shows cell cycle phase-independent nuclear expression in cancer cells.
Immunogen:    Synthetic peptide of human SYCP1
Applications:    ELISA, IHC
Recommended Dilutions:    IHC: 25-100; ELISA: 1000-2000
Host Species:    Rabbit
Clonality:    Rabbit Polyclonal
Isotype:    Immunogen-specific rabbit IgG
Purification:    Antigen affinity purification
Species Reactivity:    Human
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol
Research Areas:    Epigenetics and Nuclear Signaling
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human colon cancer tissue using 214654(SYCP1 Antibody) at a dilution of 1/35(Nucleus).

In comparision with the IHC on the left, the same paraffin-embedded Human colon cancer tissue is first treated with the synthetic peptide and then with 214654(Anti-SYCP1 Antibody) at dilution 1/35.
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