WAPL Rabbit pAb

214884

Size：100 μl Price：$ 349 Brand：NewEast Place of Origin：USA Immunogen：

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Cat.#: S214884

Product Name: Anti-WAPL Rabbit Polyclonal Antibody

Synonyms: FOE; WAPAL; KIAA0261

UNIPROT ID: Q7Z5K2 (Gene Accession - NP_055860 )

Background: WAPL (wings apart-like), also known as WAPAL or FOE, is a 1,190 amino acid protein that contains one WAPL domain and is expressed as two alternatively spliced isoforms, one of which localizes to the nucleus. Expressed in an isoform-dependent manner in heart, skeletal muscle and uterine cervix tumor tissue, WAPL is involved in sister-chromatid adhesion and overall cell growth, specifically playing a role in the development and metastasis of cancerous tissue. The gene encoding WAPL maps to human chromosome 10, which houses over 1,200 genes and comprises nearly 4.5% of the human genome. Defects in some of the genes that map to chromosome 10 are associated with Charcot-Marie Tooth disease, Jackson-Weiss syndrome, Usher syndrome, nonsyndromatic deafness, Wolman's syndrome, Cowden syndrome, multiple endocrine neoplasia type 2 and porphyria.

Immunogen: Synthetic peptide of human WAPL

Applications: ELISA, IHC

Recommended Dilutions: IHC: 20-100; ELISA: 500-1000

Host Species: Rabbit

Clonality: Rabbit Polyclonal

Isotype: Immunogen-specific rabbit IgG

Purification: Antigen affinity purification

Species Reactivity: Human, Mouse

Constituents: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol

Research Areas: Epigenetics and Nuclear Signaling, Cancer

Storage & Shipping: Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human brain tissue using 214884(WAPL Antibody) at a dilution of 1/35(Nucleus or Cytoplasm).	In comparision with the IHC on the left, the same paraffin-embedded Human brain tissue is first treated with the synthetic peptide and then with 214884(Anti-WAPL Antibody) at dilution 1/35.
The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using 214884(Anti-WAPL Antibody) at a dilution of 1/35.	In comparision with the IHC on the left, the same paraffin-embedded Human ovarian cancer tissue is first treated with synthetic peptide and then with D162487(Anti-WAPL Antibody) at dilution 1/35.

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