Email Us：info@neweastbio.com
Call Us：(+1) 610-945-2007
Size：100 μl
Price：$ 349
Brand：NewEast 
Place of Origin：USA
Immunogen：
| Cat.#: S214952 | ||||||
| Product Name: Anti-ATF6 Rabbit Polyclonal Antibody | ||||||
| Synonyms: ACHM7; ATF6A | ||||||
| UNIPROT ID: P18850 (Gene Accession - NP_031374 ) | ||||||
| Background: This gene encodes a transcription factor that activates target genes for the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Although it is a transcription factor, this protein is unusual in that it is synthesized as a transmembrane protein that is embedded in the ER. It functions as an ER stress sensor/transducer, and following ER stress-induced proteolysis, it functions as a nuclear transcription factor via a cis-acting ER stress response element (ERSE) that is present in the promoters of genes encoding ER chaperones. This protein has been identified as a survival factor for quiescent but not proliferative squamous carcinoma cells. There have been conflicting reports about the association of polymorphisms in this gene with diabetes in different populations, but another polymorphism has been associated with increased plasma cholesterol levels. This gene is also thought to be a potential therapeutic target for cystic fibrosis. | ||||||
| Immunogen: Synthetic peptide of human ATF6 | ||||||
| Applications: ELISA, WB, IHC | ||||||
| Recommended Dilutions: IHC: 50-200;WB: 500-2000;ELISA: 5000-10000 | ||||||
| Host Species: Rabbit | ||||||
| Clonality: Rabbit Polyclonal | ||||||
| Isotype: Immunogen-specific rabbit IgG | ||||||
| Purification: Antigen affinity purification | ||||||
| Species Reactivity: Human | ||||||
| Constituents: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol | ||||||
| Research Areas: Epigenetics and Nuclear Signaling | ||||||
| Storage & Shipping: Store at -20°C. Avoid repeated freezing and thawing | ||||||
|
Select By Alphabet
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Subscribe to our latest email
Add to cart
Buy now
Download
