RBFOX1 Rabbit pAb

222294

Size：100 μl Price：$ 349 Brand：NewEast Place of Origin：USA Immunogen：

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Cat.#: S222294

Product Name: Anti-RBFOX1 Rabbit Polyclonal Antibody

Synonyms: 2BP1; FOX1; A2BP1; FOX-1; HRNBP1

UNIPROT ID: Q9NWB1 (Gene Accession - NP_001135805 )

Background: The Fox-1 family of RNA-binding proteins is evolutionarily conserved, and regulates tissue-specific alternative splicing in metazoa. Fox-1 recognizes a (U)GCAUG stretch in regulated exons or in flanking introns. The protein binds to the C-terminus of ataxin-2 and may contribute to the restricted pathology of spinocerebellar ataxia type 2 (SCA2). Ataxin-2 is the product of the SCA2 gene which causes familial neurodegenerative diseases. Fox-1 and ataxin-2 are both localized in the trans-Golgi network. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Immunogen: Synthetic peptide of human RBFOX1

Applications: ELISA, IHC

Recommended Dilutions: IHC: 40-200; ELISA: 5000-10000

Host Species: Rabbit

Clonality: Rabbit Polyclonal

Isotype: Immunogen-specific rabbit IgG

Purification: Antigen affinity purification

Species Reactivity: Human, Mouse

Constituents: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol

Research Areas: Epigenetics and Nuclear Signaling, Neuroscience, Developmental Biology

Storage & Shipping: Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human liver cancer tissue using 222294(RBFOX1 Antibody) at a dilution of 1/40(Cytoplasm).	In comparision with the IHC on the left, the same paraffin-embedded Human liver cancer tissue is first treated with the synthetic peptide and then with 222294(Anti-RBFOX1 Antibody) at dilution 1/40.
The image on the left is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using 222294(Anti-RBFOX1 Antibody) at a dilution of 1/40.	In comparision with the IHC on the left, the same paraffin-embedded Human colorectal cancer tissue is first treated with synthetic peptide and then with D264346(Anti-RBFOX1 Antibody) at dilution 1/40.

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