HP1 alpha (1E8) Mouse mAb

261349

Size：100 μl Price：$ 349 Brand：NewEast Place of Origin：USA Immunogen：

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Cat.#: N261349

Product Name: Anti-HP1 alpha (1E8) Mouse Monoclonal Antibody

Synonyms: CBX5; HP1A; Chromobox protein homolog 5; Antigen p25; Heterochromatin protein 1 homolog alpha; HP1 alpha

UNIPROT ID: P45973

Background: Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.

Immunogen: Purified recombinant protein expressed in E.coli.

Applications: WB,IHC-P

Recommended Dilutions: WB: 1/500-1/1000 IHC: 1/50-1/100

Host Species: Mouse

Clonality: Mouse Monoclonal

Clone ID: 1E8-5C3-10E1

MW: Calculated MW: 22 kDa; Observed MW: 22 kDa

Isotype: IgG1

Purification: Affinity Purified

Species Reactivity: Human,Rat,Mouse

Conjugation: Unconjugated

Modification: Unmodified

Constituents: PBS (without Mg2+ and Ca2+), pH 7.3 containing 50% glycerol, 0.5% BSA and 0.02% sodium azide

Research Areas: Epigenetics and Nuclear Signaling

Storage & Shipping: Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemical analysis of paraffin-embedded Human tonsils using HP1 alpha (1E8) antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.	Immunohistochemistry analysis of paraffin-embedded Human Colon Carcinoma Tissue using HP1 alpha (1E8) antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.
Immunohistochemistry analysis of paraffin-embedded Human Placenta Tissue using HP1 alpha (1E8) antibody High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.	Western blot analysis of HP1 alpha (1E8) in COS7, Hela lysates using HP1 alpha (1E8) antibody.

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HP1 alpha (1E8) Mouse mAb

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