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Size：100 μl
Price：$ 349
Brand：NewEast 
Place of Origin：USA
Immunogen：
| Cat.#: N261403 | ||||
| Product Name: Anti-AKT Mouse Monoclonal Antibody | ||||
| Synonyms: AKT1 | ||||
| UNIPROT ID: P31749/P31751/Q9Y243 | ||||
| Background: Akt, also referred to as PKB or Rac, plays a critical role in controlling survival and apoptosis. This protein kinase is activated by insulin and various growth and survival factors to function in a wortmannin-sensitive pathway involving PI3 kinase. Akt is activated by phospholipid binding and activation loop phosphorylation at Thr308 by PDK1 and by phosphorylation within the carboxy terminus at Ser473. | ||||
| Immunogen: Purified recombinant human AKT1 protein fragments expressed in E.coli.AKT1 interacts (via the C-terminus) with CCDC88A (via its C-terminus). Interacts with GRB10; the interaction leads to GRB10 phosphorylation thus promoting YWHAE-binding By similarity. Interacts with AGAP2 (isoform 2/PIKE-A); the interaction occurs in the presence of guanine nucleotides. Interacts with AKTIP. Interacts (via PH domain) with MTCP1, TCL1A AND TCL1B. Interacts with CDKN1B; the interaction phosphorylates CDKN1B promoting 14-3-3 binding and cell-cycle progression. Interacts with MAP3K5 and TRAF6. Interacts with BAD, PPP2R5B, STK3 and STK4. Interacts (via PH domain) with SIRT1. Interacts with SRPK2 in a phosphorylation-dependent manner. Interacts with RAF1. Interacts with TRIM13; the interaction ubiquitinates AKT1 leading to its proteasomal degradation. Interacts with TNK2 and CLK2. Interacts (via the C-terminus) with THEM4 (via its C-terminus). Interacts with and phosphorylated by PDPK1.AKT2 interacts (via PH domain) with MTCP1, TCL1A AND TCL1B. Interacts with CLK2, PBH2 and TRAF6. AKT3 interacts (via PH domain) with TCL1A; this enhances AKT3 phosphorylation and activation. Interacts with TRAF6. | ||||
| Applications: WB,IP | ||||
| Recommended Dilutions: WB: 1/500-1/1000 IP: 1/20 | ||||
| Host Species: Mouse | ||||
| Clonality: Mouse Monoclonal | ||||
| Clone ID: 3B11-G8-B1 | ||||
| MW: Calculated MW: 56 kDa; Observed MW: 60 kDa | ||||
| Isotype: IgG1 | ||||
| Purification: Affinity Purified | ||||
| Species Reactivity: Human,Mouse,Rat | ||||
| Conjugation: Unconjugated | ||||
| Modification: Unmodified | ||||
| Constituents: PBS (without Mg2+ and Ca2+), pH 7.3 containing 50% glycerol, 0.5% BSA and 0.02% sodium azide | ||||
| Research Areas: Signal Transduction | ||||
| Storage & Shipping: Store at -20°C. Avoid repeated freezing and thawing | ||||
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