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kappa Opioid Receptor Rabbit mAb

262439

Size:100 μl Price:$ 349 Brand:NewEast Place of Origin:USA Immunogen:

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Cat.#:   N262439
Product Name:   Anti-kappa Opioid Receptor Rabbit Monoclonal Antibody
Synonyms:   KOR; R21; KOR-1; MSL-1; Oprk2; K-OR-1
UNIPROT ID:   P33534
Background:    G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions.
Immunogen:    A synthetic peptide of mouse Kappa Opioid Receptor
Applications:    WB,IP
Recommended Dilutions:    WB: 1/500-1/1000 IP: 1/20
Host Species:    Rabbit
Clonality:    Rabbit Monoclonal
Clone ID:    R03-2A5
MW:    Calculated MW: 43 kDa; Observed MW: 60 kDa
Isotype:    IgG
Purification:    Affinity Purified
Species Reactivity:    Rat
Conjugation:    Unconjugated
Modification:    Unmodified
Constituents:    PBS (without Mg2+ and Ca2+), pH 7.3 containing 50% glycerol, 0.5% BSA and 0.02% sodium azide
Research Areas:    Neuroscience
Storage & Shipping:    Store at -20°C. Avoid repeated freezing and thawing

Western blot analysis of Kappa Opioid Receptor in rat Brain lysates using kappa Opioid Receptor antibody.
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