Pellino 1 Rabbit mAb

262694

Size：100 μl Price：$ 349 Brand：NewEast Place of Origin：USA Immunogen：

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Cat.#: N262694

Product Name: Anti-Pellino 1 Rabbit Monoclonal Antibody

Synonyms: Pellino-related intracellular-signaling molecule; RING-type E3 ubiquitin transferase pellino homolog 1

UNIPROT ID: Q96FA3

Background: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates 'Lys-63'-linked polyubiquitination of IRAK1 allowing subsequent NF-kappa-B activation (PubMed:12496252, PubMed:17675297). Mediates 'Lys-48'-linked polyubiquitination of RIPK3 leading to its subsequent proteasome-dependent degradation; preferentially recognizes and mediates the degradation of the 'Thr-182' phosphorylated form of RIPK3 (PubMed:29883609). Negatively regulates necroptosis by reducing RIPK3 expression (PubMed:29883609). Mediates 'Lys-63'-linked ubiquitination of RIPK1 (PubMed:29883609).

Immunogen: Recombinant protein of human Pellino 1

Applications: WB,IP

Recommended Dilutions: WB: 1/500-1/1000 IP: 1/20

Host Species: Rabbit

Clonality: Rabbit Monoclonal

Clone ID: R07-0E3

MW: Calculated MW: 46 kDa; Observed MW: 46 kDa

Isotype: IgG

Purification: Affinity Purified

Species Reactivity: Human,Rat

Conjugation: Unconjugated

Modification: Unmodified

Constituents: PBS (without Mg2+ and Ca2+), pH 7.3 containing 50% glycerol, 0.5% BSA and 0.02% sodium azide

Research Areas: Signal Transduction

Storage & Shipping: Store at -20°C. Avoid repeated freezing and thawing

Western blot analysis of Pellino 1 in rat Brain, Jurkat lysates using Pellino 1 antibody.

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Product Categories

Pellino 1 Rabbit mAb

TUBB3 Rabbit pAb

GAPDH Rabbit pAb

TUBA4A Rabbit pAb

ALB Rabbit pAb

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