Rad51D Rabbit mAb

262804

Size：100 μl Price：$ 349 Brand：NewEast Place of Origin：USA Immunogen：

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Cat.#: N262804

Product Name: Anti-Rad51D Rabbit Monoclonal Antibody

Synonyms: TRAD; R51H3; BROVCA4; RAD51L3

UNIPROT ID: O75771

Background: Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. Bind to single-stranded DNA (ssDNA) and has DNA-dependent ATPase activity. Part of the Rad21 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. Involved in telomere maintenance. The BCDX2 subcomplex XRCC2:RAD51D can stimulate Holliday junction resolution by BLM.

Immunogen: Recombinant protein of human Rad51D

Applications: WB,IP

Recommended Dilutions: WB: 1/500-1/1000 IP: 1/20

Host Species: Rabbit

Clonality: Rabbit Monoclonal

Clone ID: R03-9E6

MW: Calculated MW: 35 kDa; Observed MW: 35 kDa

Isotype: IgG

Purification: Affinity Purified

Species Reactivity: Human,Mouse,Rat

Conjugation: Unconjugated

Modification: Unmodified

Constituents: PBS (without Mg2+ and Ca2+), pH 7.3 containing 50% glycerol, 0.5% BSA and 0.02% sodium azide

Research Areas: Neuroscience

Storage & Shipping: Store at -20°C. Avoid repeated freezing and thawing

Western blot analysis of Rad51D in K562, C6, 3T3, Hela lysates using Rad51D antibody.

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