Phospho-Rb2 p130 (Ser952) Rabbit mAb

262824

Size：100 μl Price：$ 349 Brand：NewEast Place of Origin：USA Immunogen：

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Cat.#: N262824

Product Name: Anti-Phospho-Rb2 p130 (Ser952) Rabbit Monoclonal Antibody

Synonyms: Rb2; P130

UNIPROT ID: Q08999

Background: Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor.

Immunogen: A synthetic phosphopeptide corresponding to residues surrounding Ser952 of human Rb2 p130

Applications: WB,IHC-F,IHC-P,ICC/IF

Recommended Dilutions: WB: 1/500-1/1000 IHC: 1/50-1/100 IF: 1/50-1/200

Host Species: Rabbit

Clonality: Rabbit Monoclonal

Clone ID: R02-5D6

MW: Calculated MW: 128 kDa; Observed MW: 128 kDa

Isotype: IgG

Purification: Affinity Purified

Species Reactivity: Human

Conjugation: Unconjugated

Modification: Phosphorylated

Constituents: PBS (without Mg2+ and Ca2+), pH 7.3 containing 50% glycerol, 0.5% BSA and 0.02% sodium azide

Research Areas: Cell Biology

Storage & Shipping: Store at -20°C. Avoid repeated freezing and thawing

Immunocytochemistry analysis of Rb2 p130 (Phospho-Ser952)(green) in Hela using Rb2 p130 (Phospho-Ser952) antibody,and DAPI(blue)	Western blot analysis of Rb2 p130 (Phospho-Ser952) in K562, Hela lysates using Phospho-Rb2 p130 (Ser952) antibody.
Immunohistochemistry analysis of paraffin-embedded Human tonsil using Rb2 p130 (Phospho-Ser952) antibody. High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.

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Phospho-Rb2 p130 (Ser952) Rabbit mAb

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