Securin Rabbit mAb

262879

Size：100 μl Price：$ 349 Brand：NewEast Place of Origin：USA Immunogen：

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Cat.#: N262879

Product Name: Anti-Securin Rabbit Monoclonal Antibody

Synonyms: PTTG1; EAP1; PTTG; TUTR1; Securin; Esp1-associated protein; Pituitary tumor-transforming gene 1 protein; Tumor-transforming protein 1; hPTTG

UNIPROT ID: O95997

Background: Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively regulates the transcriptional activity and related apoptosis activity of TP53. The negative regulation of TP53 may explain the strong transforming capability of the protein when it is overexpressed. May also play a role in DNA repair via its interaction with Ku, possibly by connecting DNA damage-response pathways with sister chromatid separation.

Immunogen: A synthetic peptide of human Securin

Applications: WB,IHC-P,IP

Recommended Dilutions: WB: 1/500-1/1000 IHC: 1/50-1/100 IP: 1/20

Host Species: Rabbit

Clonality: Rabbit Monoclonal

Clone ID: R09-6J7

MW: Calculated MW: 22 kDa; Observed MW: 25 kDa

Isotype: IgG

Purification: Affinity Purified

Species Reactivity: Human,Mouse

Conjugation: Unconjugated

Modification: Unmodified

Constituents: PBS (without Mg2+ and Ca2+), pH 7.3 containing 50% glycerol, 0.5% BSA and 0.02% sodium azide

Research Areas: Cell Biology

Storage & Shipping: Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin-embedded Human tonsil using Securin antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.

Western blot analysis of Securin in K562, 3T3, Hela lysates using Securin antibody.

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Securin Rabbit mAb

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