RET(C634Y)

26146

Size：100 μl Price：$ 495 Brand：NewEast Place of Origin：USA Immunogen：

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RET(C634Y)

Cat. #: 26146

Gene Symbol: RET, PTC, CDHF12, CAHF16, HSCR1, MEN2A, MEN2B

Description: Anti-RET(C634Y) Mouse Monoclonal Antibody

Background: RET protein is encoded by the RET proto- oncogene. It is a receptor tyrosine kinase. RET loss of function mutations are associated with the development of Hirschsprung’s disease, while gain of function mutations are associated with development of various types of human cancer, including medullary thyroid carcinoma, multiple endocrine neoplasia type 2A and 2B, pheochromocytoma and parathyroid hyperplasia.

Immunogen: A synthetic peptide from the internal region of RET which includes the mutation of C634Y, human origin.

Applications: ELISA, WB, IHC

Recommended Dilutions: ELISA: 1:1000-1:2000 WB: 1:500-1:1000 IHC: 1:50-1:100

Concentration: 0.5 mg/ml

Host Species: Mouse

Format: Liquid

Clonality: Monoclonal

Isotype: IgG

Purity: Purified from ascites

Preservative: No

Constituents: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol

Species Reactivity: Recognizes C634Y mutant, but not wild type RET of vertebrates.

Storage Conditions: Store at -20°C. Avoid repeated freezing and thawing

Western blot:

Western blot analysis of recombinant RET(C634Y) and wild type proteins. Purified His-tagged RET(C634Y) protein (lane1) and corresponding wild type protein (lane2) were blotted with Anti-RET(C634Y) monoclonal antibody (Cat. #26146).

Immunoprecipitation/Western blot:

Immunofluorescence of cells expressing RET proteins with Anti-RET(C634Y) antibody. HEK293T cells were transfected with pCDNA3-GFP-RET (WT) plasmid (left column) or pCDNA3-GFP-RET(C634Y) plasmid (right column), then fixed and stained with Anti-RET(C634Y) monoclonal antibody (Cat. #26146).

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RET(C634Y)

IDH2(R172G)

IDH2(R172W)

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