CD45 Mouse mAb

261203

Size：100 μl Price：$ 349 Brand：NewEast Place of Origin：USA Immunogen：

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Cat.#: N261203

Product Name: Anti-CD45 Mouse Monoclonal Antibody

Synonyms: PTPRC; CD45; Receptor-type tyrosine-protein phosphatase C; Leukocyte common antigen; L-CA; T200; CD antigen CD45

UNIPROT ID: P08575

Background: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported.

Immunogen: Purified recombinant fragment of human PTPRC (AA: 928-989) expressed in E. Coli.

Applications: WB,IHC-P

Recommended Dilutions: WB: 1/500-1/1000 IHC: 1/50-1/100

Host Species: Mouse

Clonality: Mouse Monoclonal

Clone ID: 5D3A3

MW: Calculated MW: 147 kDa; Observed MW: 180-240kDa

Isotype: IgG1

Purification: Affinity Purified

Species Reactivity: Human,Mouse

Conjugation: Unconjugated

Modification: Unmodified

Constituents: PBS (without Mg2+ and Ca2+), pH 7.3 containing 50% glycerol, 0.5% BSA and 0.02% sodium azide

Research Areas: Immunology

Storage & Shipping: Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin-embedded esophageal cancer tissues using PTPRC antibody with DAB staining.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.	Immunohistochemistry analysis of paraffin-embedded breast cancer tissues using PTPRC antibody with DAB staining.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.
Western blot analysis of PTPRC antibody in Ramos, Raw264.7 lysates using PTPRC antibody.

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CD45 Mouse mAb

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