Bcr Rabbit mAb

263236

Size：100 μl Price：$ 349 Brand：NewEast Place of Origin：USA Immunogen：

Add to cart

Download

Datasheet

MSDS

Product Description Reference citations(0) Related Products

Cat.#: N263236

Product Name: Anti-Bcr Rabbit Monoclonal Antibody

Synonyms: ALL; CML; PHL; BCR1; D22S11; D22S662

UNIPROT ID: P11274

Background: A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The unregulated tyrosine kinase activity of BCR-ABL1 contributes to the immortality of leukaemic cells. The BCR protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac and other kinases. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2020]

Immunogen: A synthetic peptide of human Bcr

Applications: WB,IHC-P,IP

Recommended Dilutions: WB: 1/500-1/1000 IHC: 1/50-1/100 IP: 1/20

Host Species: Rabbit

Clonality: Rabbit Monoclonal

Clone ID: R02-6I0

MW: Calculated MW: 143 kDa; Observed MW: 160 kDa

Isotype: IgG

Purification: Affinity Purified

Species Reactivity: Human,Rat

Conjugation: Unconjugated

Modification: Unmodified

Constituents: PBS (without Mg2+ and Ca2+), pH 7.3 containing 50% glycerol, 0.5% BSA and 0.02% sodium azide

Research Areas: Signal Transduction

Storage & Shipping: Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin-embedded Human Brain using Bcr antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.

Western blot analysis of Bcr in A549, HL-60, U2OS, C6 lysates using Bcr antibody.

Reference citations

No data available

Product Targets

Product Categories

Bcr Rabbit mAb

TUBB3 Rabbit pAb

GAPDH Rabbit pAb

TUBA4A Rabbit pAb

ALB Rabbit pAb

Contant Us