Human TNFSF12 Protein, hFc Tag

11223

Size：100 μg Price：$ 415 Brand：NewEast Place of Origin：USA Immunogen：

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Cat.#: 11223

Product Name: Human TNFSF12 Protein

Size : 10 µg, 50 µg and 100 µg

Synonyms: APO3L;DR3LG;TNLG4A;TWEAK

Target: TNFSF12

UNIPROT ID: O43508

Description: Recombinant Human TNFSF12 Protein with N-terminal Human Fc tag

Background: The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ligand for the FN14/TWEAKR receptor. This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution. This cytokine, which exists in both membrane-bound and secreted forms, can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. This cytokine is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis. Alternative splicing results in multiple transcript variants. Some transcripts skip the last exon of this gene and continue into the second exon of the neighboring TNFSF13 gene, such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13.

Species/Host: HEK293

Molecular Weight: The protein has a predicted molecular mass of 43.3 kDa after removal of the signal peptide.

Molecular Characterization: hFc(Glu99-Ala330) TNFSF12(Ser94-His249)

Purity: The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.

Formulation & Reconstitution: Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization.

Storage & Shipping: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Figure 1. Human TNFSF12 Protein, hFc Tag on SDS-PAGE under reducing condition.

Figure 2. ELISA plate pre-coated by 1 µg/ml (100 µl/well) Human TNFSF12 Protein, hFc Tag (11223) can bind Anti-TNFSF12 Rabbit mAb in a linear range of 3.2-80 ng/mL.

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Human TNFSF12 Protein, hFc Tag

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