Human B7-2 Protein, mFc-His Tag

11162

Size：100 μg Price：$ 415 Brand：NewEast Place of Origin：USA Immunogen：

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Cat.#: 11162

Product Name: Human B7-2 Protein

Size : 10 µg, 50 µg and 100 µg

Synonyms: CD86;B7-2;B70;CD28LG2;LAB72;MGC34413

Target: B7-2

UNIPROT ID: P42081

Description: Recombinant human B7-2 protein with C-terminal mouse Fc and 6xHis tag

Background: This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in several transcript variants encoding different isoforms.

Species/Host: HEK293

Molecular Weight: The protein has a predicted molecular mass of 52.4 kDa after removal of the signal peptide.

Molecular Characterization: B7-2(Leu26-Pro247) mFc(Pro99-Lys330) 6×His tag

Purity: The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.

Formulation & Reconstitution: Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization.

Storage & Shipping: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Figure 1. Human B7-2 Protein, mFc-His Tag on SDS-PAGE under reducing condition.

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Human B7-2 Protein, mFc-His Tag

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