Human GITR Ligand Protein, mFc-His tag

11148

Size：100 μg Price：$ 525 Brand：NewEast Place of Origin：USA Immunogen：

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Cat.#: 11148

Product Name: Human GITR Ligand Protein

Size : 10 µg, 50 µg and 100 µg

Synonyms: TNFSF18;AITRL;TL6;hGITRL;GITR Ligand

Target: GITR Ligand

UNIPROT ID: Q9UNG2

Description: Recombinant human GITR Ligand protein with N-terminal mouse Fc and C-6xHis tag

Background: The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptor TNFRSF18/AITR/GITR. It has been shown to modulate T lymphocyte survival in peripheral tissues. This cytokine is also found to be expressed in endothelial cells, and is thought to be important for interaction between T lymphocytes and endothelial cells.

Species/Host: HEK293

Molecular Weight: The protein has a predicted molecular mass of 46-53 kDa after removal of the signal peptide.

Molecular Characterization: mFc(Pro99-Lys330) GITR Ligand(Gln50-Ser177) 6×His

Purity: The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.

Formulation & Reconstitution: Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization.

Storage & Shipping: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Figure 1. Human GITR Ligand Protein, mFc-His Tag on SDS-PAGE under reducing condition.

Figure 2. Flow cytometry analysis with 1 µg/ml Human GITRL Protein, mFc-His tag (11148) on Expi293 cells transfected with human GITR (Blue histogram) or Expi293 transfected with irrelevant protein (Red histogram).

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Human GITR Ligand Protein, mFc-His tag

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