Human ADORA2A Protein, hFc Tag

11234

Size：100 μg Price：$ 389 Brand：NewEast Place of Origin：USA Immunogen：

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Cat.#: 11234

Product Name: Human ADORA2A Protein

Size : 10 µg, 50 µg and 100 µg

Synonyms: A2aR;ADORA2;RDC8

Target: ADORA2A

UNIPROT ID: P29274

Description: Recombinant human ADORA2A Protein with C-terminal Human Fc tag

Background: This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily, which is subdivided into classes and subtypes. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. This protein, an adenosine receptor of A2A subtype, uses adenosine as the preferred endogenous agonist and preferentially interacts with the G(s) and G(olf) family of G proteins to increase intracellular cAMP levels. It plays an important role in many biological functions, such as cardiac rhythm and circulation, cerebral and renal blood flow, immune function, pain regulation, and sleep. It has been implicated in pathophysiological conditions such as inflammatory diseases and neurodegenerative disorders. Alternative splicing results in multiple transcript variants. A read-through transcript composed of the upstream SPECC1L (sperm antigen with calponin homology and coiled-coil domains 1-like) and ADORA2A (adenosine A2a receptor) gene sequence has been identified, but it is thought to be non-coding. [provided by RefSeq, Jun 2013]

Species/Host: HEK293

Molecular Weight: The protein has a predicted molecular mass of 31.7 kDa after removal of the signal peptide.The apparent molecular mass of ADORA2A-hFc is approximately 35-55 kDa due to glycosylation.

Molecular Characterization: ADORA2A(Met1-Ser7) (Ser67-His77) (Asn144-Pro173) (Cys259-Pro266) hFc(Glu99-Ala330)

Purity: The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.

Formulation & Reconstitution: Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization.

Storage & Shipping: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Figure 1. Human ADORA2A Protein, hFc Tag on SDS-PAGE under reducing condition.

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Human ADORA2A Protein, hFc Tag

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