Human CD162 Protein, His Tag

11282

Size：100 μg Price：$ 445 Brand：NewEast Place of Origin：USA Immunogen：

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Cat.#: 11282

Product Name: Human CD162 Protein

Size : 10 µg, 50 µg and 100 µg

Synonyms: PSGL-1;SGL1;D162;ELPLG;electin P ligand

Target: CD162

UNIPROT ID: Q14242

Description: Recombinant Human CD162 protein with C-terminal 6xHis tag

Background: This gene encodes a glycoprotein that functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes. As such, this protein plays a critical role in leukocyte trafficking during inflammation by tethering of leukocytes to activated platelets or endothelia expressing selectins. This protein requires two post-translational modifications, tyrosine sulfation and the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans, for its high-affinity binding activity. Aberrant expression of this gene and polymorphisms in this gene are associated with defects in the innate and adaptive immune response. Alternate splicing results in multiple transcript variants.

Species/Host: HEK293

Molecular Weight: The protein has a predicted molecular mass of 31.4 kDa after removal of the signal peptide.The apparent molecular mass of CD162-His is approximately 70-100 kDa due to glycosylation.

Molecular Characterization: CD162(Leu18-Cys320) 6×His tag

Purity: The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.

Formulation & Reconstitution: Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization.

Storage & Shipping: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Figure 1. Human CD162 Protein, His Tag on SDS-PAGE under reducing condition.

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Human CD162 Protein, His Tag

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