Human IL4RA Protein, His Tag

11352

Size：100 μg Price：$ 445 Brand：NewEast Place of Origin：USA Immunogen：

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Cat.#: 11352

Product Name: Human IL4RA Protein

Size : 10 µg, 50 µg and 100 µg

Synonyms: CD124;IL-4RA;IL4RA

Target: IL4RA

UNIPROT ID: P24394

Description: Recombinant human IL4RA protein with C-terminal 6xHis tag

Background: This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Polymorphisms in this gene are also associated with resistance to human immunodeficiency virus type-1 infection. Alternate splicing results in multiple transcript variants.

Species/Host: HEK293

Molecular Weight: The protein has a predicted molecular mass of 24.6 kDa after removal of the signal peptide.The apparent molecular mass of IL4RA-His is approximately 35-55 kDa due to glycosylation.

Molecular Characterization: IL4RA(Met26-His232) 6×His tag

Purity: The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.

Formulation & Reconstitution: Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization.

Storage & Shipping: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Figure 1. Human IL4RA Protein, His Tag on SDS-PAGE under reducing condition.

Figure 2. ELISA plate pre-coated by 1 µg/ml (100 µl/well) Human IL-4RA , His tagged protein (11352) can bind Anti-IL-4RA Neutralizing antibody 28060 in a linear range of 16-80 ng/ml.

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Human IL4RA Protein, His Tag

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