Human IL6R Protein, hFc Tag

11335

Size：100 μg Price：$ 445 Brand：NewEast Place of Origin：USA Immunogen：

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Cat.#: 11335

Product Name: Human IL6R Protein

Size : 10 µg, 50 µg and 100 µg

Synonyms: CD126;gp80;IL-6R-1;IL-6RA;IL6Q;IL6RA;IL6RQ

Target: IL6R

UNIPROT ID: P08887

Description: Recombinant Human IL6R with C-terminal human Fc tag

Background: This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9.

Species/Host: HEK293

Molecular Weight: The protein has a predicted molecular mass of 64.7 kDa after removal of the signal peptide.The apparent molecular mass of IL6R-hFc is approximately 70-100 kDa due to glycosylation.

Molecular Characterization: IL6R(Leu20-Pro365) hFc(Glu99-Ala330)

Purity: The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.

Formulation & Reconstitution: Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization.

Storage & Shipping: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Figure 1. Human IL6R Protein, hFc Tag on SDS-PAGE under reducing condition.

Figure 2. ELISA plate pre-coated by 1 µg/ml (100 µl/well) Human IL6R, hFc tagged protein (11335) can bind Human IL6, mFc-His tagged protein 11160 in a linear range of 14.4-360 ng/ml.

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Human IL6R Protein, hFc Tag

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Human CB1 Full Length Protein

Human CCR4 Full Length Protein

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