Human TSLP Protein, hFc Tag

11433

Size：100 μg Price：$ 645 Brand：NewEast Place of Origin：USA Immunogen：

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Cat.#: 11433

Product Name: Human TSLP Protein

Size : 10 µg, 50 µg and 100 µg

Synonyms: TSLP

Target: TSLP

UNIPROT ID: Q969D9

Description: Recombinant Human TSLP with C-terminal human Fc tag

Background: This gene encodes a hemopoietic cytokine proposed to signal through a heterodimeric receptor complex composed of the thymic stromal lymphopoietin receptor and the IL-7R alpha chain. It mainly impacts myeloid cells and induces the release of T cell-attracting chemokines from monocytes and enhances the maturation of CD11c( ) dendritic cells. The protein promotes T helper type 2 (TH2) cell responses that are associated with immunity in various inflammatory diseases, including asthma, allergic inflammation and chronic obstructive pulmonary disease. The protein is therefore considered a potential therapeutic target for the treatment of such diseases. In addition, the shorter (predominant) isoform is an antimicrobial protein, displaying antibacterial and antifungal activity against B. cereus, E. coli, E. faecalis, S. mitis, S. epidermidis, and C. albicans. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2020]

Species/Host: HEK293

Molecular Weight: The protein has a predicted molecular mass of 41.1 kDa after removal of the signal peptide. The apparent molecular mass of TSLP-hFc is approximately 55-70 kDa due to glycosylation.

Molecular Characterization: TSLP(Thr29-Gln159) hFc(Glu99-Ala330)

Purity: The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.

Formulation & Reconstitution: Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization.

Storage & Shipping: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Figure 1. Human TSLP Protein, hFc Tag on SDS-PAGE under reducing condition.

Figure 2. ELISA plate pre-coated by 5 µg/ml (100 µl/well) Human TSLP Protein, hFc Tag (11433) can bind Anti-TSLP Neutralizing antibody 28110 in a linear range of 741-6667 ng/mL.

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Human TSLP Protein, hFc Tag

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