Human IFNAR1 Protein, hFc Tag

11561

Size：100 μg Price：$ 659 Brand：NewEast Place of Origin：USA Immunogen：

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Cat.#: 11561

Product Name: Human IFNAR1 Protein

Size : 10 µg, 50 µg and 100 µg

Synonyms: AVP;IFN-alpha-REC;IFNAR;IFNBR;IFRC

Target: IFNAR1

UNIPROT ID: P17181

Description: Recombinant Human IFNAR1 Protein with C-terminal human Fc tag

Background: The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The protein belongs to the type II cytokine receptor family and functions as an antiviral factor. [provided by RefSeq, Jul 2020]

Species/Host: HEK293

Molecular Weight: The protein has a predicted molecular mass of 73.3 kDa after removal of the signal peptide.The apparent molecular mass of IFNAR1-hFc is approximately 100-130 kDa due to glycosylation.

Molecular Characterization: IFNAR1(Lys28-Lys436) hFc(Glu99-Ala330)

Purity: The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.

Formulation & Reconstitution: Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization.

Storage & Shipping: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Figure 1. Human IFNAR1 Protein, hFc Tag on SDS-PAGE under reducing condition.

Figure 2. ELISA plate pre-coated by 2 µg/ml (100 µl/well) Human IFNAR1 Protein, hFc Tag (11561) can bind Anti-IFNAR1 Neutralizing antibody 28115 in a linear range of 0.73-187.50 ng/mL.

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Human IFNAR1 Protein, hFc Tag

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