Human IL12RB1 Protein, His Tag

11652

Size：100 μg Price：$ 689 Brand：NewEast Place of Origin：USA Immunogen：

Add to cart

Download

Datasheet

MSDS

Product Description Reference citations(0) Related Products

Cat.#: 11652

Product Name: Human IL12RB1 Protein

Size : 10 µg, 50 µg and 100 µg

Synonyms: CD212;IL-12R-BETA1;IL12RB;IMD30

Target: IL12RB1

UNIPROT ID: P42701

Description: Recombinant Human IL12RB1 Protein with C-terminal 6xHis tag

Background: The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. Mutations in this gene impair the development of interleukin-17-producing T lymphocytes and result in increased susceptibility to mycobacterial and Salmonella infections. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]

Species/Host: HEK293

Molecular Weight: The protein has a predicted molecular mass of 57.9 kDa after removal of the signal peptide. The apparent molecular mass of IL12RB1-His is approximately 70-100 kDa due to glycosylation.

Molecular Characterization: IL12RB1(Cys24-Glu540) 6×His tag

Purity: The purity of the protein is greater than 85% as determined by SDS-PAGE and Coomassie blue staining.

Formulation & Reconstitution: Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization.

Storage & Shipping: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Figure 1. Human IL12RB1 Protein, His Tag on SDS-PAGE under reducing condition.

Reference citations

No data available

Product Targets

Product Categories

Human IL12RB1 Protein, His Tag

Human CLDN6 Full Length Protein

Human CB1 Full Length Protein

Human CCR4 Full Length Protein

Human OR2H1 Full Length Protein

Contant Us