Human CRLF2 Protein, hFc Tag

11640

Size：100 μg Price：$ 415 Brand：NewEast Place of Origin：USA Immunogen：

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Cat.#: 11640

Product Name: Human CRLF2 Protein

Size : 10 µg, 50 µg and 100 µg

Synonyms: CRL2;CRLF2Y;TSLPR

Target: CRLF2

UNIPROT ID: Q9HC73

Description: Recombinant human CRLF2 protein with C-terminal human Fc tag

Background: This gene encodes a member of the type I cytokine receptor family. The encoded protein is a receptor for thymic stromal lymphopoietin (TSLP). Together with the interleukin 7 receptor (IL7R), the encoded protein and TSLP activate STAT3, STAT5, and JAK2 pathways, which control processes such as cell proliferation and development of the hematopoietic system. Rearrangement of this gene with immunoglobulin heavy chain gene (IGH) on chromosome 14, or with P2Y purinoceptor 8 gene (P2RY8) on the same X or Y chromosomes is associated with B-progenitor acute lymphoblastic leukemia (ALL) and Down syndrome ALL. Alternatively spliced transcript variants have been found for this gene.

Species/Host: HEK293

Molecular Weight: The protein has a predicted molecular mass of 48.51 kDa after removal of the signal peptide.

Molecular Characterization: CRLF2(Gln23-Lys231) hFc(Glu99-Ala330)

Purity: The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.

Formulation & Reconstitution: Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization.

Storage & Shipping: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

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Human CRLF2 Protein, hFc Tag

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