Human MRP1 Protein, hFc Tag

11705

Size：100 μg Price：$ 415 Brand：NewEast Place of Origin：USA Immunogen：

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Cat.#: 11705

Product Name: Human MRP1 Protein

Size : 10 µg, 50 µg and 100 µg

Synonyms: HDMX;MDMX;MRP1

Target: MRP1

UNIPROT ID: P33527

Description: Recombinant human MRP1 protein with C-terminal human Fc tag

Background: This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus, and shows structural similarity to p53-binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers. However, unlike MDM2 which degrades p53, this protein inhibits p53 by binding its transcriptional activation domain. This protein also interacts with MDM2 protein via the RING finger domain, and inhibits the latter's degradation. So this protein can reverse MDM2-targeted degradation of p53, while maintaining suppression of p53 transactivation and apoptotic functions. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Feb 2011]

Species/Host: HEK293

Molecular Weight: The protein has a predicted molecular mass of 56.7 kDa after removal of the signal peptide.

Molecular Characterization: MRP1(Met1-Phe33) hFc(Glu99-Ala330)

Purity: The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.

Formulation & Reconstitution: Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization.

Storage & Shipping: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

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Human MRP1 Protein, hFc Tag

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